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Nutrition Obesity Research Center at Harvard

Nutrition-related disease states such as diabetes and obesity may be treatable eventually by the use of therapies at the cellular and molecular levels. The Nutrition Obesity Research Center at Harvard seeks to establish a research environment which encourages the approach to defining common clinical nutrition research problems using the most sophisticated technology and scientific knowledge available.

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Recent Work by NORC-H Investigators

Maternal HIV treatment is associated with a decreased risk of diarrhea in their children. Using data from a large cohort in Tanzania, Dr. Chris Duggan and colleagues demonstrated that treating mothers with antiretroviral therapy (ART) was associated with a 21% reduction in the risk of diarrheal illness in their children during the first two years of life. As diarrhea is a major cause of morbidity and death in early childhood, this study provides further evidence supporting the health benefits of providing ART to all pregnant mothers worldwide. (Sztam KA, Liu E, Kupka R et al., Journal of Pediatrics, August, 2016.)

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Recent Work by NORC-H Investigators

Glucagon-like peptide-1 (GLP-1) rises after Roux-en-Y gastric bypass (RYGB), but the importance of GLP-1 in mediating the effects of RYGB is unclear. Dr. Kaplan and colleagues used the GLP-1 receptor antagonist exendin, delivered either centrally or peripherally in mice, to demonstrate that Central GLP-1 receptor antagonism did not disrupt any of the metabolic improvements seen after surgery. Peripheral antagonism partially reversed the improvement in glucose tolerance but did not affect changes in body weight. These data show a modest effect of peripheral GLP-1 receptor signaling in mediating improvements in glucose after RYGB, and suggest that central GLP-1 signaling is not required for the effects of RYGB. (Carmody JS, Munoz R, Yin H, Kaplan LM. American Journal of Physiology: Endocrinology and Metabolism, May, 2016.)

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In the News

2014 Pilot & Feasibility Project awardee Dr. Elaine Yu and 2015 awardee Dr. Elizabeth Hohmann are leading a clinical trial that will study the impact of gut bacteria on weight.

 

Please Cite the Grant!

Our work as a Center is measured in part by the contributions we make to published science. Please cite the National Institutes of Health Grant DK040561 in all publications that results from the use of NORC-H services or resources.

Contact Information

Nutrition Obesity Research Center at Harvard Medical School
Massachusetts General Hospital,
55 Fruit Street,
LON207
Boston, MA 02114
phone 617-724-9109
email: egrzejka@partners.org