Nutrition Obesity Research Center at Harvard
Nutrition-related disease states such as diabetes and obesity may be treatable eventually by the use of therapies at the cellular and molecular levels. The Nutrition Obesity Research Center at Harvard seeks to establish a research environment which encourages the approach to defining common clinical nutrition research problems using the most sophisticated technology and scientific knowledge available.
Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated
with Metabolic Disease
Recent Work by NORCH Investigators Adipose Tissue-Derived miRNAs Regulate Gene Expression in Other Tissues
Recent Work by NORC-H Investigators
Metformin is best known as first line treatment for type 2 diabetes. In recent years it has become clear that metformin has anti-cancer properties and prolongs lifespan, but the mechanism of these effects remains elusive. NORC-H investigator Dr. Alexander Soukas and colleagues determined that metformin kills human cancer cells and prolongs lifespan in the roundworm C. elegans by a common mechanism involving the nuclear pore complex and a gene of unknown function ACAD10. Wu L et al., Cell, December, 2016).